30-Minute Pizza Skillet Casserole

Name: 30 Minute Pizza Skillet Casserole
Prep time: 10 min
Cook time: 20 min
Total time: 30 min
Ingredients: 3 teaspoons olive oil, divided; 4 large flour tortillas, diced into bite sized pieces I used gluten free; 1 small zucchini, diced; 1 small summer squash, diced; 1 small red pepper, diced; 1 small green pepper, diced; 1/2 small onion, diced; 2 cloves garlic, minced; 1/2 teaspoon dried Italian seasoning; 1/2 teaspoon salt; 1/4 teaspoon black pepper; 1 cups tomato sauce; 1 cup shredded cheese, I used non-dairy; Chopped fresh basil for garnish, if desired.

Created On: April 24, 2017 | Updated: June 12, 2025 | 28 Comments

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This Pizza Skillet Casserole is so comforting and comes together in only 30 minutes. It’s a great make-ahead dinner that’s hearty, filling, and nutritious. And it comes together in just one pot.

Sickness struck again last week in this house, and it was even more severe than the previous time. It turns out you don’t get to rest as much when you have a crazy, crawling 9-month-old to look after all day. Thankfully, we are on the upswing now, though.

There’s always that feeling when you’ve recovered from being sick, when you’re so happy you’re feeling better, so you want to go out and enjoy the world. But at the same time, you’re terrified of getting sick again, so you don’t want to touch anything when you’re out and the hand sanitizer is flowing.

How To Make This 30-Minute Pizza Casserole

Olive oil
Tortillas – I used four large flour tortillas, diced into bite-sized pieces. Mine were gluten-free, but you can use flour, too.
Vegetables – I used zucchini, squash, red and green pepper, onion, and minced garlic in this recipe.
Spices – This recipe calls for Italian seasoning, salt, and black pepper.
Tomato sauce
Shredded cheese – I used non-dairy shredded cheese to make this recipe vegan.
Fresh basil – For garnish, if desired.

How To Make This One-Pot Pizza Casserole

Heat a large skillet over medium heat and add two teaspoons of olive oil, followed by the diced tortillas. Cook tortillas until browned, 5 minutes. Remove tortillas from the skillet.
Add one teaspoon of olive oil and all the diced vegetables, and cook until the vegetables have softened, 5-7 minutes. Add the garlic and cook for another minute.
Add the tortillas, tomato sauce, and spices back in, and let them simmer. Next, add 3/4 cup of cheese and stir until melted, 2-3 minutes. Top with the remaining 1/4 cup cheese and cover until melted. Garnish with fresh basil, if desired.

Recipe Tips and Thoughts

This recipe was inspired by my husband’s favorite food in the universe: pizza!
This pizza skillet casserole is adapted from one of my most popular recipes: my stove-top skillet enchiladas. It’s the same idea, cook up some veggies, add some chopped up tortillas and sauce and mix it all together and then melt some cheese in.
It’s totally delicious and so comforting!
I feel like it’s more important than ever to eat healthy when you’re sick, but at the same time, you have no energy to cook. That’s when 30-minute, one-pot meals come in really handy.

Have a question about this recipe? Ask me in the comments and I’ll get back to you ASAP.

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